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Home / Proteins & Peptide / Proteins

MCD peptide

SKU : BHP21300250

A Potent and Selective Blocker of KV1.1 and KV1.2 Channels

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Mfr.No.	STM-250, STM-250_0.5 mg, STM-250_1 mg, STM-250_10 mg, STM-250_5 mg
Description	A Potent and Selective Blocker of KV1.1 and KV1.2 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C110H192N40O24S4
Background	MCD peptide (Mast Cell Degranulating Peptide) is a 22 amino acid peptidyl toxin isolated from Apis mellifera bee venom1. MCD peptide induces histamine release from mast cells2 and release of glutamate in CA1 region of rat hippocampus in dose-dependent manner3.MCD peptide was shown to block KV1.2 channels in Xenopus oocytes4 and to inhibit KV1.1 (IC50 490 nM) and KV1.2 (IC50 440 nM) expressed in cell lines while having no effect on KV1.3, KV1.5 and KV3.15. In accordance, MCD peptide (6.4 uM) enhances the magnitude of field potentials in CA1 region as recorded in hippocampal slices6 and induces epileptiform seizures and brain damage after intracerebroventricular injection of 200 pM in rats7.
Biological Activity	MCD peptide inhibits KV1.1 and KV1.2 channels1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2587 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01499
Concentration	10 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	74601-64-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys15, and Cys5-Cys19 Asn22 - C-terminal amidation
Origin	Apis mellifera (Honeybee)

Synonyms	Mast cell degranulating peptide, MCDP, Peptide 401
Gene Id	KCNA1 ,KCNA2
Sequence	IKCNCKRHVIKPHICRKICGKN-NH2
Target	KV1.1, KV1.2 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Jentsch, J. and Mucke, H.W. (1977) Int. J. Pept. Protein Res. 9, 78. Schwartz, L.B. et al. (1979) J. Immunol. 123, 1445. Aniksztejn, L. et al. (1990) Neuroscience 35, 63. Guillemare, E. et al. (1992) Biochemistry 31, 12463. Grissmer, S. et. al. (1994) Mol. Pharmacol. 45, 1227. Southan, A.P. and Owen, D.G. (1997) British J. Pharmacol. 122, 335. Mourre, C. et al. (1997) Brain Res. 762, 223. Guillemare, E. et al. (1992) Biochemistry 31, 12463. Grissmer, S. et. al. (1994) Mol. Pharmacol. 45, 1227.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300250-1	STM-250_0.5 mg	0.5 mg	$326		Add to Cart
BHP21300250-2	STM-250_1 mg	1 mg	$444		Add to Cart
BHP21300250-3	STM-250_10 mg	10 mg	$1611		Add to Cart
BHP21300250-4	STM-250_5 mg	5 mg	$1152		Add to Cart

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