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Home / Proteins & Peptide / Proteins

kappa-Conotoxin RIIIK

SKU : BHP21300180

A Specific Potent Blocker of KV1.2 K+ Channels

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Mfr.No.	STC-650, STC-650_0.1 mg, STC-650_0.5 mg, STC-650_1 mg, STC-650_10 mg, STC-650_5 mg, STC-650_50 mcg
Description	A Specific Potent Blocker of KV1.2 K+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C106H178N34O33S6
Background	KV1.2 is a mammalian voltage-dependent K+ channel, homologous to the Drosophila Shaker K+ channel. KV1.2 was first cloned from rat brain1. Eight Shaker related genes exist in mammals constituting the KV1, subfamily of the large KV channel family of genes2.The channel is expressed in neurons and cardiac and smooth muscle tissue as well as in retina and pancreas2. The crystal structure of KV1.2 was recently solved shedding light on the structure of a mammalian voltage-dependent channel3. The functional channel is considered low voltage activated and shows very little inactivation. Therefore, this channel activity influences the membrane potential and excitability of neurons and muscle.KV1.2 channels are sensitive to high doses of TEA (560 mM) and low doses of 4-AP (0.59 mM), the "classical" non-selective potassium channel blockers.Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of which have not been determined. However, it appears that many of these peptides modulate the activity of ion channels4.kappa-Conotoxin RIIIK is a 24 amino acid peptidyl toxin isolated from the Conus radiatus (Rayed cone) venoM It blocks Shaker and TSha1 K+ channels. Additionally, it was found that kappaM-conotoxin RIIIK blocks voltage-activated K+ channels with a novel pharmacophore that does not comprise a dyad motif5.
Biological Activity	kappa-Conotoxin-RIIIK blocks KV1.2 with high potency.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2649 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P69769
Concentration	0.5 - 200 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	740843-55-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys4-Cys17, Cys5-Cys22, Cys12-Cys23 Thr24- C-terminal amidation X=Hydroxyproline
Origin	Conus radiatus (Rayed cone)

Synonyms	Kappa-M-RIIIK, Kappa- Conotoxin RIIIK, Conotoxin R3.1
Gene Id	KCNA2
Sequence	LXSCCSLNLRLCXVXACKRNXCCT-NH2
Target	KV1.2 K+ channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	McKinnon, D. (1989) J.Biol. Chem. 264, 8230. Gutman, G.A. et al. (2005) Pharmacol. Rev. 57, 473. Long S.B. et al. (2005) Science 309, 897. Terlau H. et al. (2004) Physiol. Rev. 84, 41. Al Sabi, A. et al. (2004) Biochemistry 43, 8625.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300180-1	STC-650_0.1 mg	0.1 mg	$295		Add to Cart
BHP21300180-2	STC-650_0.5 mg	0.5 mg	$1030		Add to Cart
BHP21300180-3	STC-650_1 mg	1 mg	$1647		Add to Cart
BHP21300180-4	STC-650_10 mg	10 mg	$6917		Add to Cart
BHP21300180-5	STC-650_5 mg	5 mg	$4940		Add to Cart
BHP21300180-6	STC-650_50 mcg	50 mcg	$185		Add to Cart

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