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Home / Proteins & Peptide / Proteins

kappa-Conotoxin RIIIJ

SKU : BHP21300181

Voltage-Gated K+ Channel Blocker

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Mfr.No.	STC-660, STC-660_0.1 mg, STC-660_0.5 mg, STC-660_1 mg, STC-660_10 mg, STC-660_5 mg, STC-660_50 mcg
Description	Voltage-Gated K+ Channel Blocker
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C117H184N32O36S6
Background	kappa-conotoxin RIIIJ (kappa-M-RIIIJ), is a peptide toxin belonging to the conotoxin M superfamily, and was originally isolated from Conus radiatus (Rayed cone) venoM This conopeptide inhibits the homotetrameric human KV1.2 channels (IC50 = 33 nM)3. kappa-M-RIIIJ was found to exert cardioprotective effects, presumably due to the high affinity of this peptide for mammalian KV1.2 and KV1.2- containing heteromultimers3.Voltage-gated K+ channels represent a structurally and functionally diverse group of membrane proteins. These channels establish the resting membrane potential and modulate the frequency and duration of action potentials in nerve and muscle1,2.
Biological Activity	kappa-Conotoxin RIIIJ is a blocker of KV1.2 channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2807 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0CG45
Concentration	30 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys4-Cys17, Cys5-Cys22 and Cys12-Cys23 X = Hydroxyproline
Origin	Conus radiatus (Rayed cone)

Synonyms	kappa-M-RIIIJ, Kappa-conotoxin RIIIJ
Gene Id	KCNA2
Sequence	LXXCCTXXKKHCXAXACKYKXCCKS-OH
Target	KV1.2 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Gulbis J. M. et al. (2002) Novartis Found. Symp. 245, 127 Chen, P. et al. (2010) J. Biol. Chem. 285, 14882. Hille, B. (1992) Ionic Channels of Excitable Membranes, 2nd Ed. Sunderland, MA: Sinauer Associates. Chen, P. et al. (2010) J. Biol. Chem. 285, 14882.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300181-1	STC-660_0.1 mg	0.1 mg	$615		Add to Cart
BHP21300181-2	STC-660_0.5 mg	0.5 mg	$1436		Add to Cart
BHP21300181-3	STC-660_1 mg	1 mg	$1849		Add to Cart
BHP21300181-4	STC-660_10 mg	10 mg	$5902		Add to Cart
BHP21300181-5	STC-660_5 mg	5 mg	$3575		Add to Cart
BHP21300181-6	STC-660_50 mcg	50 mcg	$379		Add to Cart

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