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Home / Proteins & Peptide / Proteins

Jingzhaotoxin-X

SKU : BHP21300237

A Blocker of KV4.2 and KV4.3 Channels

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Mfr.No.	STJ-080, STJ-080_0.1 mg, STJ-080_0.5 mg, STJ-080_1 mg, STJ-080_5 mg
Description	A Blocker of KV4.2 and KV4.3 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C164H242N46O41S6
Background	Jingzhaotoxin-X (JZTX-X) is a 31 amino acid peptidyl toxin originally isolated from the venom of the Chinese earth tiger tarantula, Chilobrachys guangxiensis 1,2. JZTX-X is a selective blocker of voltage-gated potassium (Kv)4.2 and Kv4.3 channels2.Kv channels play key roles in human physiology and pathophysiology. Among the various Kv channels, the Shal-type (Kv4) family is characterized by rapid inactivation and activation, expressing the transient potassium currents within the heart, nervous system, and a subpopulation of smooth muscle cells3. Kv4.2 channel has been identified as a potent factor contributing to the A-type currents within the dorsal horn neurons, and reside at a crucial position for regulating pain processing. Kv4.3 channels are detected within the soma of a neuronal subset of the non-peptidergic nociceptive dorsal root ganglion (DRG), which plays a critical role in the regulation of neuron excitability. Down-regulation of the Kv4.3 channel in pain-sensing neurons can boost pain sensation. JZTX-X toxin was shown to induce long-lasting mechanical hyperalgesia in an animal model2.
Biological Activity	Jingzhaotoxin-X inhibits the activation of Kv4.2 and Kv4.3 channels and exhibits long-lasting mechanical hyperalgesia in mice1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3706.4 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0CH55
Concentration	50 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-15, Cys9-21 and Cys16-28
Origin	Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)

Synonyms	JZTX-X, Jingzhaotoxin F7-15.33
Gene Id	KCND2,KCND3
Sequence	LCSREGEFCYKLRKCCAGFYCKAFVLHCYRN-OH
Target	KV4.2 and KV4.3 Channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Liao, Z. et al. (2007) Proteomics 11, 1892. Deng, M. et al. (2020) J. Venom Anim. Toxins Incl. Trop. Dis. 26, e20190043. Birnbaum, S.G. et al. (2004) Physiol. Rev. 84, 803.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300237-1	STJ-080_0.1 mg	0.1 mg	$229		Add to Cart
BHP21300237-2	STJ-080_0.5 mg	0.5 mg	$702		Add to Cart
BHP21300237-3	STJ-080_1 mg	1 mg	$1008		Add to Cart
BHP21300237-4	STJ-080_5 mg	5 mg	$3451		Add to Cart

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