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Home / Proteins & Peptide / Proteins

Hm1b Toxin

SKU : BHP21300232

An Activator of Nav1.1 and Nav1.3 Channels

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Mfr.No.	STH-655, STH-655_0.1 mg, STH-655_0.5 mg, STH-655_1 mg, STH-655_50 mcg, STH-655_5 mg
Description	An Activator of Nav1.1 and Nav1.3 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C169H241N45O50S6
Background	delta-theraphotoxin-Hm1b (Hm1b) is a 34 amino acid peptidyl toxin originally isolated from the venom of the tarantula, Heteroscodra maculata1. Hm1b acts as a potent and highly selective activator of the voltage-gated sodium (NaV) 1.1 and NaV1.3 channels. This toxin inhibits the inactivation of the human NaV1.1 channel (expressed in HEK293 cells) with an EC value of 12 nM1,2.The Hm1b toxin has a high level of sequence similarity to the Hm1a toxin, which is also a selective and specific activator of NaV1.1 channels. Both toxins are members of the extended family of inhibitor cystine knot (ICK) peptides with C1-C4, C2-C5, and C3-C6 disulfide architecture. In addition, they share secondary structure characteristics, specifically an antiparallel beta hairpin. Despite the high degree of sequence similarity between Hm1a and Hm1b, the latter is much more stable in biological fluids2.NaV channels are involved in a wide array of physiological processes and play a fundamental role in normal neurological function, especially in the initiation and propagation of action potentials. NaV1.1 channel has been utilized as a therapeutic target for various brain disorders, including epilepsy, Alzheimer's disease, and autisM The NaV1.1 channel also contributes to mechanical pain by regulating the excitability of a specific subset of sensory neurons within the peripheral nervous systeM
Biological Activity	Hm1b acts as a potent and highly selective activator of NaV1.1 and NaV1.3 voltage-gated sodium channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3895.4 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DOC5
Concentration	20 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28
Origin	Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)

Synonyms	Delta-theraphotoxin-Hm1b, Delta-TRTX-Hm1b, delta-theraphotoxin-Hm1b
Gene Id	SCN1A, SCN3A
Sequence	ECRYLFGGCKTTADCCKHLGCRTDLYYCAWDGTF-OH
Target	NaV1.1, Nav1.3, Voltage-gated Na+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Osteen, J.D. et al. (2016) Nature 534, 494. Chow, C.Y. et al. (2020) Biochem. Pharm. 181, 113991 Chow, C.Y. et al. (2020) Biochem. Pharm., 181, 113991.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300232-1	STH-655_0.1 mg	0.1 mg	$615		Add to Cart
BHP21300232-2	STH-655_0.5 mg	0.5 mg	$2033		Add to Cart
BHP21300232-3	STH-655_1 mg	1 mg	$3252		Add to Cart
BHP21300232-4	STH-655_50 mcg	50 mcg	$388		Add to Cart
BHP21300232-5	STH-655_5 mg	5 mg	$9756		Add to Cart

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