JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Proteins & Peptide / Proteins

Hm1a Toxin

SKU : BHP21300231

A Selective and Potent Activator of NaV1.1 Channels and Blocker of KV2 and KV4 Channels

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	STH-601, STH-601_0.1 mg, STH-601_0.5 mg, STH-601_1 mg, STH-601_10 mg, STH-601_5 mg, STH-601_50 mcg
Description	A Selective and Potent Activator of NaV1.1 Channels and Blocker of KV2 and KV4 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C170H240N48O53S6
Background	Hm1a Toxin (delta-TRTX-Hm1a) is a peptide toxin originally isolated from Heteroscodra maculate tarantula venoM The toxin was originally described as a KV2 and KV4 channel blocker1 but has since been found to be a selective and specific activator of NaV1.1 voltage-gated sodium channels2,3. It interacts with extracellular loops connecting transmembrane segments 1-2 and 3-4 in domain IV voltage sensor of the channel to inhibit NaV1.1 fast inactivation2,3. Hm1a inhibits human NaV1.1 channel inactivation expressed in Xenopus oocytes with EC50 value of 38 ± 6 nMNaV1.1 channel is a therapeutic target for brain disorders, such as epilepsy, Alzheimer's disease, and autisM It also contributes to mechanical pain by regulating excitability in a specific subset of sensory neurons within the peripheral nervous systeM
Biological Activity	Hm1a is a NaV1.1 specific activator1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3996.4 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P60992
Concentration	100 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28 Ser35 - C-terminal amidation
Origin	Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)

Synonyms	Delta-theraphotoxin-Hm1a, Delta-TRTX-Hm1a, Heteroscodratoxin-1, HmTx1, Kappa-theraphotoxin-Hm1a, Kappa-TRTX-Hm1a
Gene Id	KCNB1,KCNB2 ,KCND1,KCND2,KCND3,SCN1A,SCN2A,SCN3A
Sequence	ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS-NH2
Target	NaV1.1, KV2, KV4 channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Escoubas, P. et al. (2002) Mol. Pharmacol. 62, 48. Osteen, J.D. et al. (2016) Nature 534, 494. Osteen, J.D. et al. (2017) Proc. Natl. Acad. Sci. U.S.A. 114, 6836. Osteen, J.D. et al. (2016) Nature 534, 494.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300231-1	STH-601_0.1 mg	0.1 mg	$406		Add to Cart
BHP21300231-2	STH-601_0.5 mg	0.5 mg	$958		Add to Cart
BHP21300231-3	STH-601_1 mg	1 mg	$1536		Add to Cart
BHP21300231-4	STH-601_10 mg	10 mg	$6438		Add to Cart
BHP21300231-5	STH-601_5 mg	5 mg	$4024		Add to Cart
BHP21300231-6	STH-601_50 mcg	50 mcg	$262		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.