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Home / Proteins & Peptide / Proteins

Hm1a-ATTO Fluor 647N

SKU : BHP21300230

A Fluorescent Conjugate Marker for Sensitive Detection of NaV1.1 Channels

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Mfr.No.	STH-600-FRN, STH-600-FRN_10 mcg, STH-600-FRN_5 mcg
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Background	Delta-theraphotoxin-Hm1a (Hm1a) is a peptide toxin originally isolated from Heteroscodra maculate tarantula venom. Initially described as a moderate-affinity KV4.1 blocker¹, later studies confirmed it primarily targets NaV1.1 voltage-gated sodium channels²,3. It interacts with extracellular loops connecting transmembrane segments 1-2 and 3-4 in domain IV voltage sensor of the channel to inhibit NaV1.1 fast inactivation2,3. Hm1a inhibits human NaV1.1 channel inactivation expressed in Xenopus oocytes with EC50 value of 38 ± 6 nM. Recent studies show Hm1a restores interneuron firing in Scn1a+/- mice, improving inhibition in Dravet Syndrome models?. Electrophysiology confirms it prolongs NaV1.1 activation with minimal effects on NaV1.2 and Na1.6?,?. NaV1.1 channel is a therapeutic target for brain disorders, such as epilepsy, Alzheimer's disease, and autism. It also contributes to mechanical pain by regulating excitability in a specific subset of sensory neurons within the peripheral nervous system. Hm1a is a valuable tool for neuroscience and pharmacology research?-?.
Biological Activity	Hm1a is a NaV1.1 specific activator1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4625 Da
Source	Modified synthetic peptide
Concentration	100 nM - 1uM
Form	Lyophilized
Notes	Bioassay Tested: Yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	ATTO 647N (conjugated via amine group)
Origin	Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)

Synonyms	Delta-theraphotoxin-Hm1a, Delta-TRTX-Hm1a, Heteroscodratoxin-1, HmTx1, Kappa-theraphotoxin-Hm1a, Kappa-TRTX-Hm1a
Gene Id	KCNB1,KCNB2 ,KCND1,KCND2,KCND3,SCN1A,SCN2A,SCN3A
Sequence	ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS-OH
Target	NaV1.1, KV2, KV4 channels

Country Of Origin	Israel/IL
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Avoid exposure to light. Storage of solutions: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Applications	Electrophysiology, Live cell imaging, Immunofluorescence, Fluorescence staining, Direct flow cytometry

Reference	Escoubas, P. et al. (2002) Mol. Pharmacol. 62, 48. Osteen, J.D. et al. (2016) Nature 534, 494. Osteen, J.D. et al. (2017) Proc. Natl. Acad. Sci. U.S.A. 114, 6836. Goff, K.M. and Goldberg, E.M. (2019) eLife, 8, e46846. Almog, Y. et al. (2022) Front Mol Neurosci., 15, 823640. Mattis, J. et al. (2022) eLife, 11, e69293. Mora-Jimenez, L. et al. (2021) Mol Ther Nucleic Acids, 25, 585-599.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300230-1	STH-600-FRN_10 mcg	10 mcg	$821		Add to Cart
BHP21300230-2	STH-600-FRN_10 mcg	2x10 mcg	$1439		Add to Cart
BHP21300230-3	STH-600-FRN_10 mcg	5x10 mcg	$2439		Add to Cart
BHP21300230-4	STH-600-FRN_10 mcg	10x10 mcg	$3345		Add to Cart
BHP21300230-5	STH-600-FRN_5 mcg	5 mcg	$543		Add to Cart

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