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Home / Proteins & Peptide / Proteins

Hemitoxin

SKU : BHP21300227

A Potent Blocker of KV1.1, KV1.2 and KV1.3 K+ Channels

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Mfr.No.	STH-500, STH-500_0.1 mg, STH-500_0.5 mg, STH-500_10 mcg, STH-500_50 mcg
Description	A Potent Blocker of KV1.1, KV1.2 and KV1.3 K+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C159H259N49O49S8
Background	Hemitoxin is a 35 amino acid peptidyl toxin isolated from the Hemiscorpius lepturus scorpion venom and belongs to the alphaKTx6 family1. It reversibly blocks KV1.1, KV1.2 and KV1.3 voltage-gated K+ channels with an IC50 of 13 nM, 16 nM and 2 nM, respectively1. It shares 80% sequence similarity with Maurotoxin, and has a unique pairing of its four disulfide bridges1.
Biological Activity	Hemitoxin reversibly inhibits rat voltage-gated K+ channels KV1.1 (KCNA1), KV1.2 (KCNA2) and KV1.3 (KCNA3)1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3897.7 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P85528
Concentration	1 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys24, Cys9-Cys29, Cys13-Cys19 and Cys31-Cys34
Origin	Hemiscorpius lepturus (Scorpion)

Synonyms	K+ channel toxin alpha-KTx 6.15
Gene Id	KCNA1 ,KCNA2 ,KCNA3
Sequence	IKCTLSKDCYSPCKKETGCPRAKCINRNCKCYGCS-OH
Target	KV1.1, KV1.2, KV1.3 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Srairi-Abid, N. et al. (2008) FEBS J. 275, 4641. Srairi-Abid, N. et al. (2008) FEBS J. 275, 4641.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300227-1	STH-500_0.1 mg	0.1 mg	$614		Add to Cart
BHP21300227-2	STH-500_0.5 mg	0.5 mg	$1455		Add to Cart
BHP21300227-3	STH-500_10 mcg	10 mcg	$167		Add to Cart
BHP21300227-4	STH-500_50 mcg	50 mcg	$448		Add to Cart
BHP21300227-5	STH-500_10 mcg	5x10 mcg	$655		Add to Cart

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