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Home / Proteins & Peptide / Proteins

GTx1-15

SKU : BHP21300298

A Blocker of Voltage-Gated Na+ and T-Type Ca2+ Channels

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Mfr.No.	STT-300, STT-300_0.1 mg, STT-300_0.5 mg, STT-300_1 mg, STT-300_10 mg, STT-300_5 mg, STT-300_50 mcg
Description	A Blocker of Voltage-Gated Na+ and T-Type Ca2+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C176H271N53O45S7
Background	GTx1-15 is isolated from the Grammostola rosea (Phrixotrichus auratus) spider venom and is a synthetic version of the peptide1,2.GTx1-15 inhibits voltage-gated rat NaV1.3 and NaV1.7 Na+ channels, as well as T-type Ca2+ channels1,2.Voltage-gated Na+ channels (VGSC, NaV) play a critical role in excitability of nociceptors (pain-sensing neurons).The peripheral-specific Na+ channels NaV1.7, NaV1.8 and NaV1.9 are particularly important in the pathophysiology of different pain syndromes and hence, thought to be potential targets for pain therapeutics3-4. The expression and functional properties of NaV channels in peripheral sensory neurons can be dynamically regulated following axonal injury or peripheral inflammation5.GTx1-15 shows high homology to Phrixotoxin-3 (#STP-720) (76%) and Ceratotoxin-2 (#STC-100) (57%).
Biological Activity	GTx1-15 inhibits rat NaV1.3 and NaV1.7 voltage-gated Na+ channels as well as T-type Ca2+ channels.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4073.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DJA9
Concentration	200 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys17, Cys9-Cys23, Cys16-Cys30 Phe34 - C-terminal amidation
Origin	Grammostola rosea (Chilean rose tarantula) (Phrixotrichus auratus)(Grammostola spatulata)

Synonyms	omega/beta-Theraphotoxin-Ps2a, beta-TRTX-Ps2a, Peptide E, beta/omega-TRTX-Gr2a
Gene Id	CACNA1G,SCN10A,SCN1A,SCN2A,SCN3A,SCN4A,SCN5A,SCN8A,SCN9A
Sequence	DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF-NH2
Target	NaV Na+ Channels, T-type Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Meir, A., Cherki, R.S., Kolb, E., Langut, Y., Bajayo, N., 2011. Novel peptides isolated from spider venom, and uses thereof. U.S. Patent Application Publication # US 2011/0065647 A1. Ono, S. et al. (2011) Toxicon. 58, 265. Sheets, P.L. et al. (2008) J. Pharmacol. Exp. Ther. 326, 89. Zimmermann, K. et al. (2007) Nature 447, 855. Amir, R. et al. (2006) J. Pain 7, S1.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300298-1	STT-300_0.1 mg	0.1 mg	$406		Add to Cart
BHP21300298-2	STT-300_0.5 mg	0.5 mg	$1217		Add to Cart
BHP21300298-3	STT-300_1 mg	1 mg	$1659		Add to Cart
BHP21300298-4	STT-300_10 mg	10 mg	$7042		Add to Cart
BHP21300298-5	STT-300_5 mg	5 mg	$4967		Add to Cart
BHP21300298-6	STT-300_50 mcg	50 mcg	$287		Add to Cart

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