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Home / Proteins & Peptide / Proteins

GsMTx-4

SKU : BHP21300203

A Blocker of NaV1.7, TRPC1, TRPC6 and Piezo1 Channels

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Mfr.No.	STG-100, STG-100_0.1 mg, STG-100_0.5 mg, STG-100_1 mg, STG-100_10 mg, STG-100_5 mg, STG-100_50 mcg
Description	A Blocker of NaV1.7, TRPC1, TRPC6 and Piezo1 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C185H273N49O45S6
Background	GsMTx-4 is a 34 amino acid peptidyl toxin originally isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family1.This toxin inhibits different channels and in addition has antimicrobial activity. It blocks cation-selective mechanosensitive ion channels (strech-activated channels, SACs), without having an effect on whole-cell voltage-sensitive currents1. In addition, it inhibits atrial fibrillation2 as well as the membrane motor of outer hair cells3 at low doses. A medium toxicity on a large spectra of voltage-gated Na+ channels, namely NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.5, NaV1.6 and NaV1.7 was reported. GsMTx-4 also inhibits K+ channels KV11.1 and KV11.2, whereas it does not inhibit K+ channels KV1.1 (IC50 > 85 uM), KV1.4 (IC50 > 85 uM) and KV11.3 (IC50 = 53 uM)4. GsMTx-4 was also found to inhibit both TRPC1 and TRPC6 channels5,6, as well as Piezo1, the mechanosensitive channel7.Antimicrobial activity is shown against several Gram-positive and Gram-negative bacteria as well8.
Biological Activity	GsMTx-4 is an inhibitor of Na+ voltage-gated channels3 and cation-selective mechanosensitive channels1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4096 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	Q7YT39
Concentration	500 nM - 10 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	1209500-46-8
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30 Phe34 - C-terminal amidation
Origin	Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)

Synonyms	M-TRTx-Gr1a, M-theraphotoxin-Gr1a, GsMTx4
Gene Id	SCN9A, TRPC1, TRPC6, PIEZO1
Sequence	GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF-NH2
Target	NaV1.7 channels, TRPC1, TRPC6, Piezo1

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Suchyna, T.M. et al. (2000) J. Gen. Physiol. 115, 583. Bode, F. et al. (2001) Nature 409, 35. Fang, J. and Iwasa, K.H. (2006) Neurosci. Lett. 404, 213. Redaelli, E. et al. (2010) J. Biol. Chem. 285, 4130. Spassova, M.A. et al. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 16586. Alessandri-Haber, N. et al. (2009) J. Neurosci. 29, 6217. Ostrow, K.L. et al. (2003) Toxicon 42, 263. Bae, C. et al. (2011) Biochemistry 50, 6295. Ostrow, K.L. et al. (2003) Toxicon 42, 263. Suchyna, T.M. et al. (2000) J. Gen. Physiol. 115, 583. Redaelli, E. et al. (2010) J. Biol. Chem. 285, 4130.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300203-1	STG-100_0.1 mg	0.1 mg	$152		Add to Cart
BHP21300203-2	STG-100_0.5 mg	0.5 mg	$438		Add to Cart
BHP21300203-3	STG-100_1 mg	1 mg	$786		Add to Cart
BHP21300203-4	STG-100_10 mg	10 mg	$4825		Add to Cart
BHP21300203-5	STG-100_5 mg	5 mg	$3016		Add to Cart
BHP21300203-6	STG-100_50 mcg	50 mcg	$77		Add to Cart

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