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Home / Proteins & Peptide / Proteins

GpTx-1

SKU : BHP21300210

A Blocker of NaV1.7, NaV1.5 and NaV1.4 Na+ Channels

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Mfr.No.	STG-400, STG-400_0.1 mg, STG-400_0.5 mg, STG-400_1 mg, STG-400_5 mg, STG-400_50 mcg
Description	A Blocker of NaV1.7, NaV1.5 and NaV1.4 Na+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C176H271N53O45S7
Background	GpTx-1 is a 34-residue peptide with inhibitory cystine knot motif and contains 3 important residues near the C-terminus that are critical for potently blocking NaV1.7 channel, with IC50 value of 10 nM The peptide toxin was originally isolated from the Grammostola porteri spider venom1,2. In addition, GpTx-1 demonstrates selectivity against other NaV subtypes including NaV1.4 and NaV1.5 channels.There are nine mammalian subtypes of voltage-gated sodium (NaV) channels: NaV1.1-NaV1.9. These channels responsible for propagating action potentials in excitable cells and are considered to be important therapeutic targets for a wide variety of pathophysiological conditions such as cardiac arrhythmia, and epilepsy. NaV1.7 channel plays an important role in human pain signalling pathway and it is an important therapeutic target for treatment of chronic pain3,4.
Biological Activity	GpTx-1 is a NaV1.7, NaV1.5 and NaV1.4 Na+ channel blocker1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4073.9 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DL72
Concentration	10 - 200 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30 Phe34 - C-terminal amidation
Origin	Grammostola porteri (Tarantula spider) (Lasiodora porteri)

Synonyms	beta/omega-TRTX-Gr2a, Toxin GTx1-15, Beta/omega-theraphotoxin-Gr2a
Gene Id	SCN1A,SCN2A,SCN3A,SCN8A,SCN9A
Sequence	DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF-NH2
Target	NaV1.7, NaV1.5, NaV1.4 channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Murray, J.K. et al. (2015) J. Med. Chem. 58, 2299. Murray, J.K. et al. (2015) Bioorg. Med. Chem. Lett. 25, 4866. Chow, C.Y. et al. (2015) Toxins 7, 2494. Klint J.K. et al. (2015) Br. J. Pharmacol. 172, 2445. Murray, J.K. et al. (2015) J. Med. Chem. 58, 2299. Murray, J.K. et al. (2015) Bioorg. Med. Chem. Lett. 25, 4866.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300210-1	STG-400_0.1 mg	0.1 mg	$235		Add to Cart
BHP21300210-2	STG-400_0.5 mg	0.5 mg	$926		Add to Cart
BHP21300210-3	STG-400_1 mg	1 mg	$1302		Add to Cart
BHP21300210-4	STG-400_5 mg	5 mg	$4549		Add to Cart
BHP21300210-5	STG-400_50 mcg	50 mcg	$170		Add to Cart

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