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Home / Proteins & Peptide / Proteins

Fasciculin-II

SKU : BHP21300043

A Selective, Potent and Reversible Blocker of Acetylcholinesterase

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Mfr.No.	F-225, F-225_0.5 mg, F-225_1 mg, F-225_10 mg, F-225_5 mg, F-225_70 mcg
Description	A Selective, Potent and Reversible Blocker of Acetylcholinesterase
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C276H438N88O90S10
Background	Fasciculin-II is a 61 amino acid peptidyl toxin with four disulfide bonds, isolated from the Eastern green mamba (Dendroaspis angusticeps) venom. Fasciculin-II belongs to the three finger protein of Elapidae toxin family. Fasciculin-II differs from Fasciculin-I only at one position by a replacement of Tyr with Asp or Asn1.Fasciculin-II was shown to be a selective potent and reversible blocker of acetylcholinesterase by binding to the peripheral site of the enzyme1. Injection of Fasciculin-II to mice causes severe, generalized, and long-lasting twitching (fasciculation) due to its ability to prevent degradation and therefore promote acetylcholine accumulation at the neuromuscular junction2.
Biological Activity	Fasciculin-II selectively and potently binds and inhibits acetylcholinesterase.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	6749.6 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Natural protein
Accession Number	P0C1Z0
Concentration	1 - 10 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	95506-56-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys22, Cys17-Cys39, Cys41-Cys52 and Cys53-Cys59
Origin	Dendroaspis angusticeps (Eastern green mamba).

Synonyms	Fasciculin-2, Fas-2, Fas2, FAS-II, Toxin TA1, Acetylcholinesterase toxin F-VII, fasciculin, fasciculin II, fasciculin 2
Gene Id	ACHE
Sequence	TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY-OH
Target	Acetylcholinesterase (AChE)

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Acetylcholinesterase (AChE) activity

Reference	Anglister, L. et al. (1978) J. Mol. Biol. 125, 293. Karlsson, E. et al. (1986) Pharmacol. Ther. 30, 259. Ellman, G.L. et al. (1961) Biochem. Pharmacol. 7, 88. Anglister, L. et al. (1978) J. Mol. Biol. 125, 293. Ellman, G.L. et al. (1961) Biochem. Pharmacol. 7, 88.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300043-1	F-225_0.5 mg	0.5 mg	$878		Add to Cart
BHP21300043-2	F-225_1 mg	1 mg	$1177		Add to Cart
BHP21300043-3	F-225_10 mg	10 mg	$4656		Add to Cart
BHP21300043-4	F-225_5 mg	5 mg	$3508		Add to Cart
BHP21300043-5	F-225_70 mcg	70 mcg	$469		Add to Cart

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