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Home / Proteins & Peptide / Proteins

Ergtoxin-1

SKU : BHP21300202

A Novel Blocker of ERG1 (KV11.1) K+ Channel

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Mfr.No.	STE-450, STE-450_0.1 mg, STE-450_0.5 mg, STE-450_1 mg, STE-450_10 mg, STE-450_5 mg
Description	A Novel Blocker of ERG1 (KV11.1) K+ Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C193H287N59O63S9
Background	Ergtoxin-1 was originally isolated from Centruroides noxius scorpion venoMThe peptide toxin specifically blocks KV11.1 (ERG) K+ channels in different tissues and across species1,2. Patch clamp recordings from cultured cell lines and cardiac myocytes showed specific blocking of ERG currents with an IC50 of 16 nM, and increased firing rate in neurons as well as cardiac action potential broadening1,2.
Biological Activity	Ergtoxin-1 is a potent inhibitor of ERG K+ channels of nerve, heart and endocrine cells of different species1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4730 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	Q86QT3
Concentration	10 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	8006-25-5
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys5-Cys23, Cys11-Cys34, Cys20-Cys39, and Cys24-Cys41
Origin	Centruroides noxius (Mexican scorpion)

Synonyms	K+ channel toxin gamma-KTx 1.1, CnErg1, CnErgTx1, ErgTx1, ErgTx
Gene Id	KCNH2,KCNH6,KCNH7
Sequence	DRDSCVDKSRCAKYGYYQECQDCCKNAGHNGGTCMFFKCKCA-OH
Target	KV11.1 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Scaloni, A. et al. (2000) FEBS Lett. 479, 156. Gurrola, G.B. et al. (1999) FASEB. J. 13, 953. Scaloni, A. et al. (2000) FEBS Lett. 479, 156. Gurrola, G.B. et al. (1999) FASEB. J. 13, 953.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300202-1	STE-450_0.1 mg	0.1 mg	$266		Add to Cart
BHP21300202-2	STE-450_0.5 mg	0.5 mg	$768		Add to Cart
BHP21300202-3	STE-450_1 mg	1 mg	$1227		Add to Cart
BHP21300202-4	STE-450_10 mg	10 mg	$5315		Add to Cart
BHP21300202-5	STE-450_5 mg	5 mg	$3797		Add to Cart

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