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Home / Proteins & Peptide / Proteins

Conantokin R

SKU : BHP21300190

An Antagonist of GluN2A and GluN2B Receptors

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Mfr.No.	STC-777, STC-777_0.5 mg, STC-777_1 mg, STC-777_10 mg, STC-777_2.5 mg, STC-777_5 mg
Description	An Antagonist of GluN2A and GluN2B Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C127H201N35O49S3
Background	Conantokin R is a peptide toxin originally isolated from the Conus radiatus (Rayed cone) venom, and preferentially antagonizes GluN2A and GluN2B NMDA receptors1,2,4. Conantokins are a group of short linear peptides (17-27 amino acids) originally isolated from the venom of cone snails. They structurally possess a high degree of alpha-helicity in the presence of divalent cations, and contain gamma-carboxyglutamic acid residues. Four naturally occurring conantokins have been identified and characterized to date, Conantokin G, Conantokin T, Conantokin R, and Conantokin-L1,2.Conantokins appear to function by inhibiting the spermine/spermidine stimulation of ion flow through the NMDAR channel and different conantokin species present different NMDA receptor subunit specificity3.NMDR inhibition by conantokins is related to various human pathologies including pain, convulsive disorders, stroke, and Parkinson's disease. The potential pharmacological selectivity of conantokins, coupled to their efficacy in preclinical disease model and favorable safety profiles, indicate that these peptides represent both novel probes for NMDA receptor function as well as an important class of compounds for continued investigation as human therapeutics1.
Biological Activity	Conantokin R is a potent and non-competitive NMDA receptor 2A/B antagonist1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3098 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P58806
Concentration	50 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	202925-60-8
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys21-Cys25 X = 4-Carboxyglutamate
Origin	Conus radiatus (Rayed cone)

Synonyms	Con-R
Gene Id	GluN2A, GluN2B, GRIN2A, GRIN2B, GRIN2C, GRIN2D
Sequence	GEXXVAKMAAXLARXNIAKGCKVNCYP-OH
Target	GluN2B receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Layer, R.T. et al. (2004) Curr. Med. Chem. 11, 3073. Prorok, M. and Castellino, F.J. (2001) Curr. Drug Targets 2, 313. Castellino, F.J. and Prorok, M. (2000) Curr. Drug Targets 3, 219. White, H.S. et al. (2000) J. Pharmacol. Exp. Ther. 292, 425.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300190-1	STC-777_0.5 mg	0.5 mg	$202		Add to Cart
BHP21300190-2	STC-777_1 mg	1 mg	$306		Add to Cart
BHP21300190-3	STC-777_10 mg	10 mg	$1547		Add to Cart
BHP21300190-4	STC-777_2.5 mg	2.5 mg	$607		Add to Cart
BHP21300190-5	STC-777_5 mg	5 mg	$969		Add to Cart

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