JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Proteins & Peptide / Proteins

Angiotensin II

SKU : BHP21300048

A Ligand of AT1 and AT2 G-Protein Coupled Receptors

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	GPA-100, GPA-100_1 mg, GPA-100_10 mg, GPA-100_100 mg, GPA-100_25 mg, GPA-100_5 mg, GPA-100_50 mg
Description	A Ligand of AT1 and AT2 G-Protein Coupled Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C50H71N13O12
Background	Angiotensin II (Ang II) is a key factor in the Renin-Angiotensin-Aldosterone (RAAS) systeM Ang II is a derivative of a precursor molecule - angiotensinogen, a member of the serpin family. Angiotensinogen is a substrate of the Renin in the kidney to produce a deca peptide - Ang I, which appears to have no biological activity. Ang I is converted to Ang II by Angiotensin-Converting Enzyme (ACE)1,2.The biological effects caused by Ang II are mediated by four Ang II receptor subtypes: AT1 and AT2. Ang II plays a critical role in the regulation of the renal and cardiovascular systems, and some activities in the central nervous systems. Circulating levels of Ang II were identified as controlling blood pressure, based on the regulation of salt and water metabolism, vascular smooth muscle cell tone, thirst, and sympathetic system outflow. Ang II is well known to cause potent increases in systemic and local blood pressure via its vasoconstrictive effect, to influence renal tubules, to retain Na+ and water by activating Na+/H+ exchangers, and by stimulating aldosterone release from the adrenal gland3.Ang II is also a cell growth modulator depending on the Ang II receptor subtype expressed in the cell membrane. It may either stimulate growth (proliferation, hypertrophy) or act as a growth suppressor3,4.
Biological Activity	Angiotensin II regulates blood vessel tonus, blood pressure, and salt and water balance1-3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1046.2 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01019
Concentration	1 - 300 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	4474-91-3
UNSPSC Code	12352202
Lead Time	1-2 Business Days

Synonyms	Ang II, Angiotensin-2
Gene Id	AGTR1, AGTR2
Sequence	DRVYIHPF-OH
Target	Angiotensin II receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Western blot

Reference	Basso, N. and Terragno, N.A. (2001) Hypertension 38, 1246. Santos, R.A. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8258. Kim, S. and Iwao, H. (2000) Pharmacol. Rev. 52, 11. Dinh, D.T. et al. (2001) Clinical Science 100, 481. Watanabe, T. et al. (2005) Hypertension 45, 163. Keidar, S. et al. (2007) Cardiovasc Res. 73, 463. Gendron, L. et al. (1999) Mol. Endocrinol. 13, 1615.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300048-1	GPA-100_1 mg	1 mg	$40		Add to Cart
BHP21300048-2	GPA-100_10 mg	10 mg	$147		Add to Cart
BHP21300048-3	GPA-100_100 mg	100 mg	$421		Add to Cart
BHP21300048-4	GPA-100_25 mg	25 mg	$211		Add to Cart
BHP21300048-5	GPA-100_5 mg	5 mg	$61		Add to Cart
BHP21300048-6	GPA-100_50 mg	50 mg	$273		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.