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Home / Proteins & Peptide / Proteins

alphaA-Conotoxin PIVA

SKU : BHP21300176

A Potent Antagonist of Muscle Fetal alpha1/beta1/gamma/delta nAChR

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Mfr.No.	STC-600, STC-600_0.1 mg, STC-600_0.5 mg, STC-600_1 mg, STC-600_5 mg, STC-600_50 mcg
Description	A Potent Antagonist of Muscle Fetal alpha1/beta1/gamma/delta nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C103H150N34O37S6
Background	alphaA-Conotoxin PIVA is the first member of a new family of nAChR-targeted Conus peptides, named short alphaA-conotoxins1. It is a peptide toxin originally isolated from Conus Purpurascens (Purple cone) venom1.This peptide reversibly blocks postsynaptic muscle fetal alpha1/beta1/gamma/delta nicotinic ACh receptor1,2 . It also blocks postsynaptic muscle adult alpha1/beta1/epsilon/delta nicotinic ACh receptor, with lower affinity (IC50 of 22 nM to the adult compared to 2.3 nM to the fetal nAChR)2.alphaA-conotoxin PIVA has a strikingly different amino acid sequence and a Cys framework from all other nAChR-targeted peptides previously characterized from Conus venoms. Despite the striking structural divergence, the peptide blocks the ACh binding site of the nAChR at the neuromuscular junction, similar to the well known typical of a-conotoxins1.The characterization of the short alphaA-conotoxins revealed diverse kinetics of a block of the fetal muscle nAChR, particularly in dissociation rates. The structure-function relationships of native alphaA-conotoxins revealed a single amino acid locus (alternatively either His or Pro) that is a critical determinant of the dissociation kinetics2.
Biological Activity	alphaA-Conotoxin PIVA reversibly blocks muscle alpha1/beta1/gamma/delta nicotinic ACh receptor1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2649 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P55963
Concentration	1 - 20 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys16, Cys3-Cys11 and Cys14-Cys23 X = Hydroxyproline Gln25 - C-terminal amidation
Origin	Conus purpurascens (Purple cone)

Synonyms	Alpha-A-conotoxin PIVA, Alpha-conotoxin PIVA
Gene Id	CHRNA1,CHRNB1,CHRND,CHRNE,CHRNG
Sequence	GCCGSYXNAACHXCSCKDRXSYCGQ-NH2
Target	alpha1/beta1/gamma/delta nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Hopkins, C. et al. (1995) J. Biol. Chem. 270, 22361. Teichert, R.W. et al. (2006) Biochemistry 45, 1304. Hopkins, C. et al. (1995) J. Biol. Chem. 270, 22361. Teichert, R.W. et al. (2006) Biochemistry 45, 1304.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300176-1	STC-600_0.1 mg	0.1 mg	$425		Add to Cart
BHP21300176-2	STC-600_0.5 mg	0.5 mg	$1268		Add to Cart
BHP21300176-3	STC-600_1 mg	1 mg	$1648		Add to Cart
BHP21300176-4	STC-600_5 mg	5 mg	$4688		Add to Cart
BHP21300176-5	STC-600_50 mcg	50 mcg	$287		Add to Cart

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