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Home / Proteins & Peptide / Proteins

alphaA-Conotoxin OIVA

SKU : BHP21300173

An Antagonist of alpha1/beta1/gamma/delta (fetal muscle) nAChR

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Mfr.No.	STC-520, STC-520_0.1 mg, STC-520_10 mcg, STC-520_50 mcg
Description	An Antagonist of alpha1/beta1/gamma/delta (fetal muscle) nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C70H110N24O23S6
Background	alphaA-Conotoxin OIVA (alphaA-OIVA) is a peptidyl toxin originally isolated from Conus obscures and belongs to the family of short alphaA-conotoxins (alphaAS) which includes alphaA-OIVA, alphaA-OIVB, alphaA-PeIVA, and alphaA-PeIVB. alphaA-Conotoxin OIVA blocks the fetal muscular subtype nicotinic acetylcholine receptor (alpha1/beta1/gamma/delta subunits) (IC50 = 0.51 nM) with 600-fold greater affinity than the adult subtype (IC50 = 310 nM). It completely blocks the elicited currents and it dissociates very slowly from the fetal muscle receptor. This toxin causes an apparently irreversible paralysis upon intramuscular injection into gold fish.1
Biological Activity	alphaA-Conotoxin OIVA blocks alpha1/beta1/g/d (fetal muscle) nAChR1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1848 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P69746
Concentration	100 - 250 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys9, Cys2-Cys14 and Cys12-Cys18 X=Hydroxyproline Cys18 - C-terminal amidation
Origin	Conus obscurus (Obscure cone) (Conus halitropus)

Synonyms	Alpha-A-O4a, Alpha-A-OIVA
Gene Id	CHRNA1,CHRNB1,CHRND,CHRNG
Sequence	CCGVXNAACHXCVCKNTC-NH2
Target	alpha1/beta1/gamma/delta nAChR

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Teichert, R.W. et al. (2006) Biochemistry 45, 1304.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300173-1	STC-520_0.1 mg	0.1 mg	$448		Add to Cart
BHP21300173-2	STC-520_10 mcg	10 mcg	$129		Add to Cart
BHP21300173-3	STC-520_50 mcg	50 mcg	$354		Add to Cart
BHP21300173-4	STC-520_10 mcg	5x10 mcg	$506		Add to Cart
BHP21300173-5	STC-520_50 mcg	5x50 mcg	$1403		Add to Cart

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