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Home / Proteins & Peptide / Proteins

alpha-Latrotoxin

SKU : BHP21300070

An Inducer of Neurotransmitter Release

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Mfr.No.	LSP-130, LSP-130_0.2 mg, LSP-130_40 mcg
Description	An Inducer of Neurotransmitter Release
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. Soluble in water. Once dissolved in water, add an equal volume of glycerol. Do not shake or vortex. Avoid multiple freeze-thaw cycles to maintain biological activity.
Background	alpha-Latrotoxin is a 130 kDa protein toxin from the black widow spider venom and is the only protein in the venom that affects mammals.1,2 Application of the toxin to presynaptic preparations induces, after a delay, a huge increase in spontaneous neurotransmitter release, which can be evaluated by measuring the post synaptic response in the form of miniature end plate potentials. This toxin is widely used to induce and study neurotransmitter release, but the molecular mechanism of its action is not fully determined.alpha-Latrotoxin is isolated according to a modified protocol as described by Frontali3 and Grasso4.
Biological Activity	alpha-Latrotoxin induces exhaustive neurotransmitter release from nerve terminals1. Indirectly activates the ERK MAP kinase pathway.
Formulation	Lyopholized in 20mM KPO4 pH 6.8.
Molecular Weight	130 kDa
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in water. Once dissolved in water, add an equal volume of glycerol. Do not shake or vortex. Avoid multiple freeze-thawing cycles.
Source	Natural protein
Accession Number	P23631
Concentration	150 pM - 1 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: yes Is Toxin: Yes
Cas Number	65988-34-3
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Highly disulfide bridged protein Glycosylated
Origin	Latrodectus tredecimguttatus (Mediterranean black widow spider).

Synonyms	alpha-Latrotoxin-Lt1a, alpha-LTX-Lt1a, alpha-LTX
Gene Id	ADGRL1,NRXN1,PTPRS
Target	Neurexin-1, ADGRL1 (latrophilin-1/CIRL), and tyrosine-protein phosphatase S (PTPRS) receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology, Synaptic recording

Reference	Ushkaryov, Y. et al. (2002) Toxicon 40, 1. Frontali, B. et al. (1976) J. Cell Biol. 68, 462. Grasso, A. et al. (1976) Biochim. Biophys. Acta. 439, 406. Sudhof, T.C. et al. (2001) Annu. Rev. Neurosci. 24, 933. Frontali, N. et al. (1976) J. Cell Biol. 68, 462.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300070-1	LSP-130_0.2 mg	0.2 mg	$1008		Add to Cart
BHP21300070-2	LSP-130_40 mcg	40 mcg	$586		Add to Cart
BHP21300070-3	LSP-130_40 mcg	5x40 mcg	$2328		Add to Cart

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