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Home / Proteins & Peptide / Proteins

alpha-Conotoxin TxID

SKU : BHP21300148

A Potent Antagonist of alpha3/beta4 Neuronal nAChR.

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Mfr.No.	STC-110, STC-110_0.1 mg, STC-110_0.5 mg, STC-110_1 mg, STC-110_10 mg, STC-110_5 mg
Description	A Potent Antagonist of alpha3/beta4 Neuronal nAChR.
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C58H92N18O18S5
Background	alpha-Conotoxin TxID (a-CTx TxID) is a 15 amino acid peptidyl toxin isolated from the mollusk-hunting cone snail, Conus textile. This toxin belongs to the alpha-4/6 conotoxin (alpha-CTx) subfamily, that potently blocks the alpha3beta4 nicotinic acetylcholine receptor (nAChR) subtype with high selectivity. In addition, alpha-CTx TxID blocks the closely related alpha6/alpha3beta4 nAChR but exhibits minimal activity towards other nAChR subtypes. alpha-CTx TxID is the most potent alpha3beta4 nAChR antagonist characterized thus far and has a unique selectivity profile 1.Neuronal nAChRs are widely distributed throughout the central and peripheral nervous systems. These receptors play important roles in normal physiology and are involved in many diseases such as epilepsy, pain, addiction, Alzheimer's disease, Parkinson's disease, schizophrenia, as well as breast and lung carcinoma. The alpha3beta4 nAChR is the most prevalent subtype in the brain and is associated with nicotine addiction, neuropathic pain and small cell lung cancer2. Given the diverse functions of the nAChRs, the a-CTx TxID may be a valuable tool for elucidating the distinct roles of the alpha3beta4 nAChRs in a variety of normal and pathological processes1,3. a-CTx TxID has been used for these purposes and it was recently shown to exhibit anti-tumor activity, which may provide novel strategies for cancer treatment4.
Biological Activity	alpha-Conotoxin TxID is a potent alpha3/beta4 nAChR antagonist and alpha6/alpha3beta4 blocker1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1489.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	K8DWB5
Concentration	20 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	1496617-64-1
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8, Cys3-Cys15Cys15 - C-terminal amidation
Origin	Conus textile (Cloth-of-gold cone)

Synonyms	Alpha-conotoxin TxID, alpha-CTx TxID
Gene Id	CHRNA3,CHRNA6,CHRNA2, CHRNB4
Sequence	GCCSHPVCSAMSPIC-NH2
Target	alpha3/beta4 nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Luo, S. et al. (2013) J Med Chem., 56, 9655. Xu, P. et al. (2019) FEBS Open Bio., 9, 1561. Yu, J. et al. (2018) J Med Chem., 61, 9256. Qian, J. et al. (2019) Eur J Pharmacol., 865, 172674.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300148-1	STC-110_0.1 mg	0.1 mg	$184		Add to Cart
BHP21300148-2	STC-110_0.5 mg	0.5 mg	$640		Add to Cart
BHP21300148-3	STC-110_1 mg	1 mg	$1023		Add to Cart
BHP21300148-4	STC-110_10 mg	10 mg	$5821		Add to Cart
BHP21300148-5	STC-110_5 mg	5 mg	$3639		Add to Cart

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