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Home / Proteins & Peptide / Proteins

alpha-Conotoxin MII

SKU : BHP21300144

A selective alpha3beta2 and alpha6beta2* subtype nAChRs Antagonist

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Mfr.No.	STC-040, STC-040_0.1 mg, STC-040_0.5 mg, STC-040_1 mg, STC-040_5 mg
Description	A selective alpha3beta2 and alpha6beta2* subtype nAChRs Antagonist
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C67H103N23O22S4
Background	alpha-Conotoxin MII is a 16 amino acid peptidyl toxin originally isolated from the venom of the marine snail, Conus magus1. This toxin was initially thought to be a selective antagonist for alpha3beta2 nicotinic acetylcholine receptors (nAChRs)1. Subsequently, it has been shown that alpha-conotoxin MII is also an alpha6beta2* nAChR subtype selective antagonist2 and it potently blocks beta3-containing neuronal nAChRs3.Neuronal nAChRs are a heterogeneous family of ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. These different receptor subtypes have a pentameric structure consisting of the homomeric or heteromeric combination of 12 different subunits (alpha2-alpha10, beta2-beta4)4.nAChRs are critically important for neuronal survival and cognitive function, as well as regulation of neurodegenerative diseases, including Alzheimer's and Parkinson's. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition. Thus, the subunit makeup of the nAChR subtypes is central to understanding their function in the nervous system and for discovering new subtype-selective drugs4-6.
Biological Activity	A potent antagonist of nAChRs composed of alpha3beta2 and alpha6beta2 subunits1,2. Also, potently blocks beta3-containing neuronal nicotinic receptors3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1711 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P56636
Concentration	5 - 20 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	175735-93-0
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8, Cys3-Cys16 Cys16 - C-terminal amidation
Origin	Conus magus (Magical cone)

Synonyms	Alpha-Ctx MII, Alpha-conotoxin MII, Alpha-MII
Gene Id	CHRNA6,CHRNA3,CHRNB2,CHRNB4,CHRNA4,CHRNA7
Sequence	GCCSNPVCHLEHSNLC-NH2
Target	alpha3beta2, alpha6beta2 nAChRs

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Cartier, G.E. et al. (1996) J. Biol. Chem., 271, 7522. Kuryatov, A. et al. (2000) Neuropharmacology, 39, 2570. McIntosh, J.M. et al. (2000) Eur. J. Pharmacol. 393, 205. Zoli, M. et al. (2015) Neuropharmacology, 96, 302. Gotti, C. et al. (2009) Biochem. Pharmacol., 78, 703. Levin, E.D. et al. (2006) Psychopharmacology 184, 523. Kuryatov, A. et al. (2000) Neuropharmacol., 39, 2570. McIntosh, J.M. et al. (2000) Eur. J. Pharmacol. 393, 205.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300144-1	STC-040_0.1 mg	0.1 mg	$185		Add to Cart
BHP21300144-2	STC-040_0.5 mg	0.5 mg	$438		Add to Cart
BHP21300144-3	STC-040_1 mg	1 mg	$703		Add to Cart
BHP21300144-4	STC-040_5 mg	5 mg	$2460		Add to Cart

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