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Home / Proteins & Peptide / Proteins

alpha-Conotoxin ImI-ATTO Fluor-590

SKU : BHP21300032

A Potent Antagonist of Mammalian alpha3/beta2 nAChR Conjugated to the Fluorescent Dye ATTO-590

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Mfr.No.	C-290-AR, C-290-AR_10 mcg
Description	A Potent Antagonist of Mammalian alpha3/beta2 nAChR Conjugated to the Fluorescent Dye ATTO-590
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Background	alpha-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom1, which blocks mammalian neuronal nAChRs located on postsynaptic membranes. This toxin inhibits mammalian neuronal nAChRs (alpha3/beta2 > alpha7 > alpha3/beta4) in a voltage-independent manner and has no effect on nAChRs composed of alpha2/beta2, alpha3/beta2, alpha4/beta2, alpha2/beta4, alpha3/beta4, or alpha4/beta4 subunits1,2.
Biological Activity	alpha-Conotoxin ImI potently and specifically blocks mammalian neuronal nAChR (alpha3/beta2 > alpha7 > alpha3/beta4)1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1924 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Source	Modified synthetic peptide
Concentration	1 - 2 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8, Cys3-Cys12 Cys12 - C-terminal amidation ATTO Fluor-590
Origin	Conus imperialis (Imperial cone)

Synonyms	alpha-CTx ImI, alpha-conotoxin ImI, Alpha-CTx ImI
Gene Id	CHRNA3,CHRNA7 ,CHRNB2,CHRNB4
Sequence	GCCSDPRCAWRC-NH2
Target	alpha3/beta2 nAChR

Country Of Origin	Israel/IL
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Applications	Electrophysiology, Live cell imaging, Immunofluorescence, Fluorescence staining

Reference	McIntosh, J.M. et al. (1994) J. Biol. Chem. 269, 16733. Johnson, D.S. et al. (1995) Mol. Pharmacol. 48, 194.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300032-1	C-290-AR_10 mcg	10 mcg	$468		Add to Cart
BHP21300032-2	C-290-AR_10 mcg	5x10 mcg	$1360		Add to Cart
BHP21300032-3	C-290-AR_10 mcg	10x10 mcg	$1897		Add to Cart

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