JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Proteins & Peptide / Proteins

alpha-Conotoxin GI

SKU : BHP21300170

A Potent Antagonist of alpha1/beta1/delta/gamma nAChR

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	STC-500, STC-500_0.5 mg, STC-500_1 mg, STC-500_10 mg, STC-500_2.5 mg, STC-500_5 mg
Description	A Potent Antagonist of alpha1/beta1/delta/gamma nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C55H80N20O18S4
Background	alpha-Conotoxin GI is a 13 amino acid peptidyl toxin isolated from the Conus geographus (Geography cone) venom1,2,3. It belongs to the Conotoxin A superfamily and reversibly blocks alpha/delta nicotinic ACh channel receptors (nAChR).alpha-Conotoxin GI reversibly inhibits the high affinity alpha/delta site on mouse muscle-derived BC3H-1 receptor, a nAChR expressed on postsynaptic membranes4,5. Other low site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ is also inhibited by alpha-Conotoxin GI5.
Biological Activity	alpha-Conotoxin GI inhibits alpha/delta site on mouse muscle-derived BC3H-1 nicotinic acetylcholine receptors (nAChR) expressed on postsynaptic membranes. Other site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ is also inhibited by alpha-Conotoxin GI1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1437.6 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	X5I9Y2
Concentration	10 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	76862-65-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys7, Cys3-Cys13 Cys13 - C-terminal amidation
Origin	Conus geographus (Geography cone) (Nubecula geographus)

Synonyms	alpha-Conotoxin G1, Alpha-conotoxin GI
Gene Id	CHRNA1,CHRNB1,CHRND,CHRNG, CHRNE
Sequence	ECCNPACGRHYSC-NH2
Target	alpha1/beta1/delta/gamma nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Gray, W.R. et al. (1981) The J. Biol. Chem. 256, 4734. Nishiuchi, Y. and Sakakibara, S. (1982) FEBS LETT. 148, 260. Guddat, L.W. et al. (1996) Biochemistry 35, 11329. Groebe, D.R. et al. (1995) Mol. Pharmacol. 48, 105. Groebe, D.R. et al. (1997) Biochemistry 36, 6469. Groebe, D.R. et al. (1995) Mol. Pharmacol. 48, 105. Groebe, D.R. et al. (1997) Biochemistry 36, 6469.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300170-1	STC-500_0.5 mg	0.5 mg	$130		Add to Cart
BHP21300170-2	STC-500_1 mg	1 mg	$240		Add to Cart
BHP21300170-3	STC-500_10 mg	10 mg	$1001		Add to Cart
BHP21300170-4	STC-500_2.5 mg	2.5 mg	$372		Add to Cart
BHP21300170-5	STC-500_5 mg	5 mg	$626		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.