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Home / Proteins & Peptide / Proteins

alpha-Conotoxin GeXIVA

SKU : BHP21300156

A Potent Antagonist of alpha9alpha10 nAChR, a Weak Antagonist of other nAChRs.

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Mfr.No.	STC-220, STC-220_0.1 mg, STC-220_0.5 mg, STC-220_1 mg, STC-220_10 mg, STC-220_5 mg, STC-220_50 mcg
Description	A Potent Antagonist of alpha9alpha10 nAChR, a Weak Antagonist of other nAChRs.
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C139H227N55O41S4
Background	alpha-Conotoxin GeXIVA (alphaO-conotoxin GeXIVA or GeXIVA) is a 28 amino acid peptidyl toxin, which was discovered from a transcriptome analysis of the South China Sea mollusk, Conus generalis1. GeXIVA belongs to the O1-gene superfamily and is a potent and selective antagonist of the alpha9alpha10 nicotinic acetylcholine receptor (nAChR) subtype1. The toxin-mediated blockade of alpha9alpha10 nAChRs is voltage-dependent, suggesting that the toxin binding site might be allosterically coupled to a voltage-sensitive domain of the nAChR1,2. GeXIVA exhibits analgesic activity in animal models of pain without the development of tolerance1-4.nAChRs are involved in a wide range of physiological functions in the central and peripheral nervous systems. Alterations in nAChR expression and/or function are associated with a number of pathophysiological conditions including pain, addiction, epilepsy, autism, schizophrenia, Alzheimer's and Parkinson's diseases, as well as many types of cancers2,6. The nAChRs are formed from the assembly of five homologous subunits and neuronal nAChRs are assembled from a combination of alpha- and beta-subunits. They share a common basic structure, but their pharmacological and functional properties arise from the wide range of different subunit combinations which generate distinctive subtypes6. The alpha9alpha10 nAChR subtype is a potential target for treating chronic pain, wound healing, the pathophysiology of the auditory system, and various cancers4-7. GeXIVA potently alleviated neuropathic pain in several rat models1-4 and also exhibited an antitumor effect5,8.
Biological Activity	A potent and selective antagonist of the alpha9alpha10 nAChR. GeXIVA exhibits analgesic activity in animal models of pain without the development of tolerance1-4.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3453 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	J7GY56
Concentration	5 - 20 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	2010167-25-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	The native disulfide bond pairing has not been studied.
Origin	Conus generalis (General cone)

Synonyms	Alpha-conotoxin GeXIVA, Conotoxin Ge14.1, Conotoxin GeXIVAWT, Alpha-O-conotoxin GeXIVA
Gene Id	CHRNA9, CHRNA10
Sequence	TCRSSGRYCRSPYDRRRRYCRRITDACV-OH
Target	alpha9alpha10 nAChRs

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Luo, S. et al. (2015) PNAS, 112, E4026. Zhangsun, D. et al. (2017) Neuropharmacol., 127, 243. Wang, H. et al. (2019), Mar. Drugs, 17, 265. Li, X. et al. (2016) Prog. Neuro-Psychopharmacol. Biol. Psych., 66, 112. Sun, Z. et al. (2020) Mar. Drugs, 18, 195. Gotti, C. et al. (2009) Biochem. Pharmacol., 78, 703. Vincler, M. et al. (2006) PNAS, 103, 17880. Liu, Y. et al. (2019) Mar. Drugs, 17, 256.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300156-1	STC-220_0.1 mg	0.1 mg	$449		Add to Cart
BHP21300156-2	STC-220_0.5 mg	0.5 mg	$1566		Add to Cart
BHP21300156-3	STC-220_1 mg	1 mg	$2505		Add to Cart
BHP21300156-4	STC-220_10 mg	10 mg	$13858		Add to Cart
BHP21300156-5	STC-220_5 mg	5 mg	$8766		Add to Cart
BHP21300156-6	STC-220_50 mcg	50 mcg	$281		Add to Cart

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