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Home / Proteins & Peptide / Proteins

alpha-Conotoxin AuIB

SKU : BHP21300160

An Antagonist of Mammalian alpha3/beta4 Neuronal nAChR and GABA(B) receptor agonist

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Mfr.No.	STC-310, STC-310_0.1 mg, STC-310_0.25 mg, STC-310_0.5 mg, STC-310_1 mg, STC-310_10 mg, STC-310_5 mg
Description	An Antagonist of Mammalian alpha3/beta4 Neuronal nAChR and GABA(B) receptor agonist
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C65H89N17O21S4
Background	alpha-Conotoxin AuIB is a 15 amino acid peptidyl toxin isolated from Conus aulicus1. This toxin inhibits mammalian neuronal alpha3/beta4 nicotinic acetylcholine receptor (nAChR) channels expressed in Xenopus oocytes with an IC50 of 0.75 uM Furthermore, alpha-Conotoxin AuIB blocks the alpha3/beta4 receptor with >100-fold higher potency than other receptor subunit combinations1.In accordance, alpha-Conotoxin AuIB (1-5 uM) blocks 20-35% of the nicotine-stimulated norepinephrine release from rat hippocampal synaptosomes1 and the nicotinic ACh receptors on dissociated neurons of the rat parasympathetic ganglia with IC50 of 1.2 nM2.alpha-Conotoxin AuIB also mediates inhibition of N-type calcium channels at nanomolar concentrations (IC50 = 1.5 nM in rat DRG neurons) via agonism of gamma-aminobutyric acid (GABA) G protein-coupled (GABAB) receptors3. GABAB receptors are promising targets for the treatment of various neurological and psychiatric disorders, including pain, depression, and drug addiction. GABAB receptors are widely expressed and distributed in pain-processing pathways at all levels of the neuraxis and play an extensive role in editing and modulating nociceptive inputs. alpha-Conotoxin AuIB produced reversal of allodynia in the partial nerve ligation (PNL) model3,4.
Biological Activity	alpha-Conotoxin AuIB potently and specifically blocks mammalian neuronal nAChR channels alpha3/beta41 and modulates high-voltage-activated (HVA) calcium channel through agonism of G-protein-coupled GABAB receptors 2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1572.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P56640
Concentration	0.1 - 5 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	216299-21-7
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8 and Cys3-Cys15 Cys15 - C-terminal amidation
Origin	Conus aulicus (Princely cone)

Synonyms	Alpha-conotoxin AuIB
Gene Id	CHRNA3,CHRNB4,CHRNA7, GABBR1 ,GABBR2
Sequence	GCCSYPPCFATNPDC-NH2
Target	alpha3/beta4 nAChR, GABA(B) receptor agonist

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Luo, S. et al. (1998) J. Neurosci. 18, 8571. Dutton, J.L. et al. (2002) J. of Biol. Chem. 277, 48849. Klimis, H. et al. (2011) Pain 152, 259. Kennedy, A.C. et al. (2020) Toxins 12, 505.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300160-1	STC-310_0.1 mg	0.1 mg	$152		Add to Cart
BHP21300160-2	STC-310_0.25 mg	0.25 mg	$262		Add to Cart
BHP21300160-3	STC-310_0.5 mg	0.5 mg	$417		Add to Cart
BHP21300160-4	STC-310_1 mg	1 mg	$666		Add to Cart
BHP21300160-5	STC-310_10 mg	10 mg	$3723		Add to Cart
BHP21300160-6	STC-310_5 mg	5 mg	$2327		Add to Cart

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