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Home / Proteins & Peptide / Proteins

alpha-Conotoxin AuIA

SKU : BHP21300197

An Antagonist of alpha3/beta4 nAChR

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Mfr.No.	STC-960, STC-960_0.25 mg, STC-960_0.5 mg, STC-960_1 mg, STC-960_5 mg
Description	An Antagonist of alpha3/beta4 nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C72H96N18O24S4
Background	Small peptide toxins of Conus origin are highly useful tools for exploring ligand nicotinic acetylcholine receptors (nAChRs) interactions1. There are three alpha-conotoxin AuIs found in Conus aulicus: AuIA, AuIB and AuIC. alpha-Conotoxin AuIA is a 16 amino acid peptidyl toxin, belonging to neuronal alpha 4/7 subfamily of alpha-conotoxins. This toxin inhibits mammalian neuronal alpha3/beta4 nicotinic acetylcholine receptor channels expressed in Xenopus oocytes. At relatively low concentrations (0.3 and 1.0 uM), this conotoxin is selective and inhibits only alpha3/beta4 subtypes2.
Biological Activity	alpha-Conotoxin AuIA is a blocker of alpha3/beta4 nAChR subtypes1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1726 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P56639
Concentration	5 - 20 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	216299-20-6
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8 and Cys3-Cys16 Cys16 - C-terminal amidation
Origin	Conus aulicus (Princely cone)

Synonyms	Alpha-conotoxin AuIA
Gene Id	CHRNA3,CHRNB4
Sequence	GCCSYPPCFATNSDYC-NH2
Target	alpha3/beta4 nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Janes, R.W. et al. (2005) Curr. Opin. Pharmacol. 5, 280. Luo, S. et al. (1998) J. Neurosci. 18, 8571. Luo, S. et al. (1998) J. Neurosci. 18, 8571.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300197-1	STC-960_0.25 mg	0.25 mg	$235		Add to Cart
BHP21300197-2	STC-960_0.5 mg	0.5 mg	$341		Add to Cart
BHP21300197-3	STC-960_1 mg	1 mg	$543		Add to Cart
BHP21300197-4	STC-960_5 mg	5 mg	$1624		Add to Cart

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