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Home / Proteins & Peptide / Proteins

Aa1 Toxin

SKU : BHP21300101

A Novel Blocker of Shaker-B and IA K+ Channels

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Mfr.No.	RTA-400, RTA-400_0.1 mg, RTA-400_10 mcg, RTA-400_5 mcg
Description	A Novel Blocker of Shaker-B and IA K+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C156H260N54O49S6
Background	Native Aa1 was originally isolated from Androctonus australis scorpion venoM Aa1 blocks Shaker B channels expressed in Xenopus oocytes with IC50=4.5 uM1 In addition, the Aa1 toxin was shown to block the fast (A-type) K+ current in cerebellum granular cells (IC 50 =134 nM,2 or Kd = 150 nM3). In both cases the block is non-voltage-dependent and does not affect kinetic parameters of the K+ currents.
Biological Activity	Aa1 Toxin is a blocker of A-type voltage-gated transient K+ channels of cerebellar granular cells1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3868 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Recombinant, E. coli
Accession Number	Q867F4
Concentration	100 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys8-Cys28, Cys13-Cys33, and Cys17-Cys35
Origin	Androctonus australis (Sahara scorpion)

Synonyms	K+ channel toxin alpha-KTx 15.4, AaTX1
Gene Id	KCNA4, KCND1, KCND2, KCND3
Sequence	QNETNKKCQGGSCASVCRRVIGVAAGKCINGRCVCYP-OH
Target	A-type KV4 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Pisciotta, M. et al. (1998) Biochem. Biophys. Res. Comm. 242, 287. Pisciotta, M. et al. (1998) Eur. Biophys. J. 27, 69. Pisciotta, M. et al. (2000) Biochim. Biophys. Acta. 1468, 203.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300101-1	RTA-400_0.1 mg	0.1 mg	$1008		Add to Cart
BHP21300101-2	RTA-400_10 mcg	10 mcg	$295		Add to Cart
BHP21300101-3	RTA-400_5 mcg	5 mcg	$211		Add to Cart
BHP21300101-4	RTA-400_10 mcg	5x10 mcg	$1162		Add to Cart
BHP21300101-5	RTA-400_5 mcg	5x5 mcg	$832		Add to Cart

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