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Home / Primary Antibodies / Polyclonal Antibodies

USP19 antibody

SKU : BHA10809298

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Mfr.No.	FNab09314
Alternative Names	Deubiquitinatingenzyme19 ; KIAA0891 ; Ubiquitinthiolesterase19 ; USP19 ; ZMYND9
Background	Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in tu stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in tuover of endoplasmic-reticulum-associated degradation(ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol(E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
Categories	Primary Antibodies
Cellular Localization	endoplasmic reticulum, Membrane
Clonality	polyclonal
Description	Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in tu stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in tuover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
Host	Rabbit
Immunogen	ubiquitin specific peptidase 19
Isotype	IgG
Molecular Weight	70 kDa, 160 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Endoplasmic reticulum, Membrane
Synonyms	Deubiquitinating enzyme 19, KIAA0891, Ubiquitin thiolesterase 19, USP19, ZMYND9

Uniprot	O94966
Research Area	Epigenetics, Metabolism
Weight	150kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000
IP	1:200-1:2000

Tested Application

WB: 1:500-1:2000

Manual	FNab09314.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809298	FNab09314	100ug	$300		Add to Cart

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