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Home / Primary Antibodies / Polyclonal Antibodies

UBE3A antibody

SKU : BHA10809180

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Mfr.No.	FNab09189
Alternative Names	ANCR ; AS ; E6AP ; E6AP ; E6APubiquitinproteinligase ; EPVE6AP ; FLJ26981 ; HPVE6A ; UBE3A ; ubiquitinproteinligaseE3A
Background	This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is mateally expressed in brain and biallelically expressed in other tissues. Mateally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alteative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus, Proteasome
Clonality	polyclonal
Description	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
Host	Rabbit
Immunogen	ubiquitin protein ligase E3A
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus, Proteasome
Synonyms	ANCR, AS, E6 AP, E6AP, E6AP ubiquitin protein ligase, EPVE6AP, FLJ26981, HPVE6A, UBE3A, ubiquitin protein ligase E3A

Uniprot	Q05086
Gene Id	7337
Research Area	Epigenetics, Metabolism
Weight	100kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, IP

Description

ELISA ; WB ; IHC ; IF ; IP

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IP	1:200-1:1000
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09189.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809180	FNab09189	100ug	$300		Add to Cart

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