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Home / Primary Antibodies / Promotion

UBE2A antibody

SKU : BHA10809155

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Mfr.No.	FNab09163
Alternative Names	HHR6A ; HR6A ; RAD6homologA ; RAD6A ; UBC2 ; UBE2A ; UbiquitincarrierproteinA ; UbiquitinproteinligaseA
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alteative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Uclear Chromatin
Clonality	polyclonal
Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Host	Rabbit
Immunogen	ubiquitin-conjugating enzyme E2A (RAD6 homolog)
Isotype	IgG
Molecular Weight	Refer to figures
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm,nuclear chromatin
Synonyms	HHR6A, HR6A, RAD6 homolog A, RAD6A, UBC2, UBE2A, Ubiquitin carrier protein A, Ubiquitin protein ligase A

Uniprot	P49459
Gene Id	7319
Research Area	Epigenetics, Cell Division and Proliferation, Metabolism
Weight	17kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab09163.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809155	FNab09163	100ug	$300		Add to Cart

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