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Home / Primary Antibodies / Promotion

TWIST1 antibody

SKU : BHA10809109

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Mfr.No.	FNab09117
Background	TWIST1, a basic helix-loop-helix protein which acts as a transcriptional regulator, plays a central role in differentiation of mesodermal during embryogenesis. It is also implicated in tumorigenesis, invasion and metastasis. TWIST1 forms both homodimers(45KD) and heterodimers with E2A E proteins, and dimer partner selection is a critical mediator of TWIST function.(PMID:14724576, 16502419).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patteing and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
Host	Rabbit
Immunogen	twist homolog 1
Isotype	IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ACS3, bHLHa38, BPES2, BPES3, H twist, SCS, TWIST, twist homolog 1(Drosophila), Twist related protein 1, TWIST1

Uniprot	Q15672
Gene Id	7291
Research Area	Epigenetics, Developmental biology, Metabolism, Cardiovascular, Stem Cells, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:200-1:1000

Manual	FNab09117.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809109	FNab09117	100ug	$300		Add to Cart

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