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Home / Primary Antibodies / Polyclonal Antibodies

TRIM63 antibody

SKU : BHA10808984

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Mfr.No.	FNab08992
Alternative Names	FLJ32380 ; IRF ; IrisRINGfingerprotein ; MuRF1 ; MURF1 ; MURF2 ; RINGfingerprotein28 ; RNF28 ; SMRZ ; TRIM63 ; tripartitemotifcontaining63
Background	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Host	Rabbit
Immunogen	tripartite motif-containing 63
Isotype	IgG
Molecular Weight	40 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	FLJ32380, IRF, Iris RING finger protein, MuRF 1, MURF1, MURF2, RING finger protein 28, RNF28, SMRZ, TRIM63, tripartite motif containing 63

Uniprot	Q969Q1
Gene Id	84676
Research Area	Epigenetics, Cardiovascular, Metabolism, Signal Transduction
Weight	40kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF

Dilution

WB	1:200-1:1000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Manual	FNab08992.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808984	FNab08992	100ug	$300		Add to Cart

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