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Home / Primary Antibodies / Promotion

RUNX2 antibody

SKU : BHA10807528

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Mfr.No.	FNab07536
Alternative Names	AML3 ; CBFA1 ; OSF2 ; PEBP2A
Background	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE)(By similarity). Inhibits KAT6B-dependent transcriptional activation.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Host	Rabbit
Immunogen	runt-related transcription factor 2
Isotype	IgG
Molecular Weight	50-60 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	AML3, CBFA1, OSF2, PEBP2A

Uniprot	Q13950
Gene Id	860
Research Area	cancer, Developmental biology, Stem Cells, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000

Tested Application

WB: 1:200-1:2000

Manual	FNab07536.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807528	FNab07536	100ug	$300		Add to Cart

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