The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alteatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
protein tyrosine phosphatase, receptor type, A
Isotype
IgG
Molecular Weight
70 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
PTPA, PTPRL2
Uniprot
P18433
Gene Id
5786
Research Area
Signal Transduction, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)