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Home / Primary Antibodies / Polyclonal Antibodies

PAWR antibody

SKU : BHA10806158

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Mfr.No.	FNab06166
Alternative Names	PAR4
Background	The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Host	Rabbit
Immunogen	PRKC, apoptosis, WT1, regulator
Isotype	IgG
Molecular Weight	43 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	PAR4

Uniprot	Q96IZ0
Gene Id	5074
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab06166.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806158	FNab06166	100ug	$300		Add to Cart

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