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Home / Primary Antibodies / Promotion

OLR1 antibody

SKU : BHA10805982

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Mfr.No.	FNab05990
Alternative Names	CLEC8A ; LOX1
Background	This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, intealizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alteate splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor that mediates the recognition, intealization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria.
Host	Rabbit
Immunogen	oxidized low density lipoprotein (lectin-like) receptor 1
Isotype	IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CLEC8A, hLOX 1, Lectin like oxLDL receptor 1, LOX 1, LOX1, OLR1, Ox LDL receptor 1, SCARE1

Uniprot	P78380
Gene Id	4973
Research Area	Immunology, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab05990.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805982	FNab05990	100ug	$300		Add to Cart

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