This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Host
Rabbit
Immunogen
methionine adenosyltransferase I, alpha
Isotype
IgG
Molecular Weight
44 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
AMS1, MATA1
Uniprot
Q00266
Gene Id
4143
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)