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Home / Primary Antibodies / Promotion

LRP5 antibody

SKU : BHA10804840

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Mfr.No.	FNab04848
Alternative Names	LR3 ; LRP7
Background	This gene encodes a transmembrane low-density lipoprotein receptor that binds and intealizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alteative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in tu, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta- catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patteing of the epiblast during gastrulation (By similarity).
Host	Rabbit
Immunogen	low density lipoprotein receptor-related protein 5
Isotype	IgG
Molecular Weight	180 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	LR3, LRP7

Uniprot	O75197
Gene Id	4041
Research Area	Developmental biology, Cardiovascular, Metabolism, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04848.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804840	FNab04848	100ug	$300		Add to Cart

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