Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation(PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes(TSGs) in colorectal cancer(CRC) cells in a ZNF304-dependent manner(PubMed:24623306).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).
Host
Rabbit
Immunogen
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Isotype
IgG
Molecular Weight
21 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
C K RAS, c Ki ras, GTPase KRas, K Ras 2, K RAS2A, K RAS2B, K RAS4A, K RAS4B, KI RAS, KRAS, KRAS1, KRAS2, KRAS2B speicifc, Krasa, Krasb, NS3, RASK2
Antigen
KRAS
Uniprot
P01116
Gene Id
3845
Research Area
Cell Division and Proliferation, Cancer, Immunology, Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)