IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
insulin-like growth factor 1 receptor
Isotype
IgG
Molecular Weight
70 kDa,90-100 kDa, 130 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
CD221, IGFIR, IGFR, JTK13
Antigen
IGF1R-Specific
Uniprot
P08069
Gene Id
3480
Research Area
Developmental biology, Signal Transduction, Metabolism, Immunology, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)