Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG. GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.
Clonality
polyclonal
Host
Rabbit
Immunogen
guanine nucleotide binding protein (G protein), alpha 13
Immunogen Region
guanine nucleotide binding protein (G protein), alpha 13