This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alteatively spliced transcript variants have been found for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Host
Rabbit
Immunogen
carboxylesterase 2 (intestine, liver)
Isotype
IgG
Molecular Weight
62kd
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
CE-2;CES2A1;PCE-2;iCE
Uniprot
O00748
Gene Id
8824
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)