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Home / Primary Antibodies / Promotion

CDH23 antibody

SKU : BHA10801543

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Mfr.No.	FNab01548
Alternative Names	KIAA1774 ; KIAA1812
Background	This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alteative splice variants encoding different isoforms have been described.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Host	Rabbit
Immunogen	cadherin-like 23
Isotype	IgG
Molecular Weight	59 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	KIAA1774, KIAA1812

Uniprot	Q9H251
Gene Id	64072
Research Area	Developmental biology, Immunology, Signal Transduction, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab01548.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801543	FNab01548	100ug	$300		Add to Cart

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