The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
BCL2-antagonist/killer 1
Isotype
IgG
Molecular Weight
26 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
Apoptosis regulator BAK, BAK, BAK LIKE, BAK1, CDN1
Uniprot
Q16611
Gene Id
578
Research Area
Cancer, Immunology, Cardiovascular, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)