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Home / Primary Antibodies / Promotion

APLP1 antibody

SKU : BHA10800481

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Mfr.No.	FNab00486
Background	This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alteatively spliced transcript variants encoding different isoforms have been described.
Categories	Primary Antibodies
Clonality	polyclonal
Description	May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Host	Rabbit
Immunogen	amyloid beta (A4) precursor-like protein 1
Isotype	IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Antigen	APLP1
Uniprot	P51693
Gene Id	333
Research Area	Developmental biology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab00486.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800481	FNab00486	100ug	$300		Add to Cart

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