Antagonizes the binding of 2-5A(5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA tuover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Clonality
polyclonal
Host
Rabbit
Immunogen
ATP-binding cassette, sub-family E(OABP), member 1
Immunogen Region
ATP-binding cassette, sub-family E(OABP), member 1
Isotype
IgG
Molecular Weight
50-70 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Subcellular Location
Cytoplasm, Mitochondrion
Synonyms
ABCE1, RLI, RNase L inhibitor, RNASEL1, OABP
Uniprot
P61221
Gene Id
6059
Research Area
Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10351.pdf" target="_blank">Data Sheet</ a>