• Alternative Names :
• Tau PFFs, Tau PFF, Tau protein Pre-formed Fibrils, Tau aggregates, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse Tau protein, P301S mutant Tau, 2N4R Tau, Tau441

• Biological Activity :
• Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when tau monomers (SPR-473) are combined with tau fibrils (SPR-471).

• Cellular Localization :
• Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex

• Certificate Of Analysis :
• Certified >95% pure using SDS-PAGE analysis.

• Field Of Use :
• Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Scientific Background :
• Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).

• Species :
• Human

• Specificity :
• ~45.8 kDa

• Accession Number :
• NP_005901.2

• Concentration :
• Lot/batch specific. See included datasheet.

• Purification :
• Ion-exchange Purified

• Expression System :
• Baculovirus

• Amino Acid Sequence :
• MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L

• Biological Activity Abreviation :
• Active

• Cite This Product :
• Human Recombinant Tau Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-471B)

• Nature :
• Recombinant

• Other Relevant Information :
• SPR-471 is post-translationally modified due to baculovirus/SF9 insect cells expression system.

• Protein Length :
• Full Length

• Gross Weight (kg) :
• 1.4

• Launch Date :
• 2020/04/04

• Net Weight (g) :
• 0.01

• Swissprot :
• P10636

• Target Details :
• Tau-441 (2N4R) P301S Mutant

• Gene Id :
• 4137

• Research Area :
• Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton

• Antigen :
• Tau

• Adr Code :
• Non-hazardous

• Country Of Origin :
• Canada

• Tarriff Code :
• 3822.19.0030

• Un Code For Transport :
• Non-hazardous

• Unspsc Code :
• 12352202

• Shipping Temperature :
• Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

• Buffer :
• PBS pH 7.4

• Purity :
• >95%

• Storage :
• -80 °C

• Storage Buffer :
• PBS pH 7.4

• Storage Temperature :
• -80°C

• Reference :
• 1. www.alz.org/alzheimers-dementia/facts-figures<br />2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907)<br />3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497.<br />4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18.<br />5. Bugiani, O. et al. (1999). J Neuropathol Exp Neurol. 58(6):667-77.

• Product Manual :
• <a href="https://www.stressmarq.com/wp-content/uploads/Protein-MSDS.pdf" target="_blank">Datasheet</a>

• SDS :
•