• Alternative Names :
• Alpha synuclein protein, Alpha-synuclein oligomer, Alpha synuclein protein oligomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein oligomers, Alpha Synuclein Protein Oligomers, SYN protein, Parkinson's disease familial 1 Protein

• Cellular Localization :
• Cytoplasm, Membrane, Nucleus

• Certificate Of Analysis :
• Certified >95% pure using SDS-PAGE analysis.

• Field Of Use :
• Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Scientific Background :
• Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Epigallocatechin Gallate (EGCG) reduces alpha synuclein fibril formation in favour of spherical soluble oligomers (7).

• Species :
• Human

• Specificity :
• ~14.46kDa

• Accession Number :
• NP_000336.1

• Concentration :
• Lot/batch specific. See included datasheet.

• Purification :
• Ion-exchange Purified

• Expression System :
• E. coli

• Biological Activity Abreviation :
• Under Investigation

• Cite This Product :
• Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-469B)

• Nature :
• Recombinant

• Protein Length :
• Full length

• Gross Weight (kg) :
• 1.4

• Launch Date :
• 2019/03/18

• Net Weight (g) :
• 0.1

• Swissprot :
• P37840 

• Target Details :
• Alpha Synuclein Oligomers

• Gene Id :
• 6622

• Research Area :
• Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience

• Antigen :
• Alpha Synuclein

• Adr Code :
• Non-hazardous

• Country Of Origin :
• Canada

• Tarriff Code :
• 3822.19.0030

• Un Code For Transport :
• Non-hazardous

• Unspsc Code :
• 12352202

• Shipping Temperature :
• Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

• Buffer :
• PBS pH 7.4

• Purity :
• >95%

• Storage :
• -80 °C

• Storage Buffer :
• PBS pH 7.4

• Storage Temperature :
• -80°C

• Reference :
• 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).<br />2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.<br />3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.<br />4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.<br />5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.<br />6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.<br />7. Ehrnhoefer, D. E. et al. (2008). Nat Struct Mol Biol. 15(6):558-566.<br />

• Product Manual :
• <a href="https://www.stressmarq.com/wp-content/uploads/Protein-MSDS.pdf" target="_blank">Datasheet</a>

• SDS :
•