• Alternative Names :
• Tau monomer, Tau protein monomer, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Monomer, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid Tau protein fragment, Truncated Tau Protein

• Biological Activity :
• Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when truncated tau fragment (AA297-391) (dGAE) monomer is combined with truncated tau fragment (AA297-391) (dGAE) pre-formed fibrils (Type 1).

• Cellular Localization :
• Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex

• Certificate Of Analysis :
• Certified >95% pure using SDS-PAGE analysis.

• Field Of Use :
• Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Scientific Background :
• Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3).

• Species :
• Human

• Specificity :
• 10.165 kDa

• Accession Number :
• NP_005901.2

• Concentration :
• Lot/batch specific. See included datasheet.

• Purification :
• Ion-exchange Purified

• Expression System :
• E. coli

• Biological Activity Abreviation :
• Active

• Cite This Product :
• Human Recombinant Tau Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-444B)

• Nature :
• Recombinant

• Protein Length :
• Fragment

• Gross Weight (kg) :
• 1.4

• Launch Date :
• 2019/03/18

• Swissprot :
• P10636

• Target Details :
• Truncated Tau Fragment (AA297-391) (dGAE)

• Gene Id :
•  4137

• Research Area :
• Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton

• Antigen :
• Tau

• Adr Code :
• Non-hazardous

• Country Of Origin :
• Canada

• Tarriff Code :
• 3822.19.0030

• Un Code For Transport :
• Non-hazardous

• Unspsc Code :
• 12352202

• Shipping Temperature :
• Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

• Buffer :
• PBS pH 7.4

• Purity :
• >95%

• Storage :
• -80 °C

• Storage Buffer :
• PBS pH 7.4

• Storage Temperature :
• -80°C

• Reference :
• 1. www.alz.org/alzheimers-dementia/facts-figures<br />2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907)<br />3. Al-Hilaly, Y.K. et al. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. J. Mol. Biol. 429(23):3650-3665 (2017)

• Product Manual :
• <a href="https://www.stressmarq.com/wp-content/uploads/Protein-MSDS.pdf" target="_blank">Datasheet</a>

• SDS :
•