• Alternative Names :
• N-acetylated Alpha synuclein monomer, N-terminal acetylated Alpha-synuclein monomer, Alpha synuclein protein monomer, Alpha synuclein monomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein monomers, SYN protein, Parkinson's disease familial 1 Protein, N?terminal Ac?alphasyn

• Biological Activity :
• Seeds aggregation of N-acetylated alpha synuclein monomer (SPR-331) in thioflavin T assay

• Cellular Localization :
• Cytoplasm, Membrane, Nucleus

• Certificate Of Analysis :
• Acetylation cofirmed via ESI mass spectrometry

• Field Of Use :
• Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Scientific Background :
• Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein purified from both normal and pathological brain tissue is N-acetylated (7) and this post-translational modification affects affect alpha-synuclein stability and toxicity (8).

• Species :
• Human

• Specificity :
• ~14.46kDa

• Accession Number :
• NP_000336.1

• Concentration :
• Lot/batch specific. See included datasheet.

• Purification :
• Ion-exchange Purified

• Expression System :
• E. coli

• Biological Activity Abreviation :
• Active

• Cite This Product :
• Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-331B)

• Nature :
• Recombinant

• Protein Length :
• Full Length

• Gross Weight (kg) :
• 1.4

• Launch Date :
• 2021/02/08

• Net Weight (g) :
• 0.01

• Swissprot :
• P37840 

• Target Details :
• Alpha Synuclein N-Terminal Acetylated

• Gene Id :
• 6622

• Research Area :
• Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience

• Antigen :
• Alpha Synuclein

• Adr Code :
• Non-hazardous

• Country Of Origin :
• Canada

• Tarriff Code :
• 3822.19.0030

• Un Code For Transport :
• Non-hazardous

• Unspsc Code :
• 12352202

• Shipping Temperature :
• Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

• Buffer :
• PBS pH 7.4

• Purity :
• >95%

• Storage :
• -80 °C

• Storage Buffer :
• PBS pH 7.4

• Storage Temperature :
• -80°C

• Reference :
• 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).<br />2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.<br />3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.<br />4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.<br />5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.<br />6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.<br />7. Anderson, J.P. et al. (2006) J Biol Chem. 2006;281:29739–29752.<br />8. Vinueza-Gavilanes, R. et al. (2020) Neurobiol Dis. 137, 2020, Article 104783

• Product Manual :
• <a href="https://www.stressmarq.com/wp-content/uploads/Protein-MSDS.pdf" target="_blank">Datasheet</a>

• SDS :
•