• Clonality :
• Monoclonal

• Description :
• Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

• Formulation :
• 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Host :
• Mouse

• Immunogen Region :
• A recombinant human partial protein (amino acids 379-491) was used as the immunogen for the Desmoglein 3 antibody.

• Isotype :
• IgG2b,kappa

• Predicted Reactivity :
• Human

• Reactivity :
• Human

• Recombinant :
• No

• Subcellular Location :
• Cell surface

• Antigen :
• Desmoglein 3

• Uniprot :
• P32926

• Clone No :
• DSG3/2796

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• Protein G affinity chromatography

• Storage :
• Store the Desmoglein 3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/desmoglein-3-antibody-dsg3-2796-v7722" target="_blank">Data Sheet</a>